Should I shoot JPEG Small instead of JPEG Large?

Yes. You'll save the planet's beaches because you use less silicon (files are smaller so you can use smaller cards). 

Okay, sarcasm aside, the answer is still Yes. Image quality should be a little better and you'll hit the buffer boundary far less often (and maybe never, as most of the Nikon cameras can shoot 100 shots continuously at any JPEG Medium or JPEG Small setting).  

Of course, you can't print such images as large. This only works if your normal output is something like Facebook or the Web.

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